tag:blogger.com,1999:blog-4287560491211025099.post3978339262174016170..comments2023-09-22T08:24:01.913-04:00Comments on Antibiotics - The Perfect Storm: It's the Resistance, Stupid!David Shlaeshttp://www.blogger.com/profile/00228776693058791618noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-4287560491211025099.post-84433573477489344522019-09-30T07:48:04.518-04:002019-09-30T07:48:04.518-04:00Thanks for this blog post admin, you have done rea...Thanks for this blog post admin, you have done really nice work.<br /><a href="https://njaddictionresources.com" rel="nofollow">best drug rehab in nj</a>Teresita Kennedyhttps://www.blogger.com/profile/07110404795450483758noreply@blogger.comtag:blogger.com,1999:blog-4287560491211025099.post-47420879472989774682019-09-24T12:54:05.035-04:002019-09-24T12:54:05.035-04:00Discovering drugs in anticipation of a market that...Discovering drugs in anticipation of a market that does not currently exist is exceedingly challenging, but that may be the way we will need to operate in the future. However, how does a medicinal chemist optimize microbiological activity, if we don't know what organism, or resistance mechanism, should be used for the SAR? It is good to try to look ahead, but we were led astray in the 1980s when we anticipated AmpC beta-lactamases to be our next major problem--not expecting the surge of ESBLs which became our next major challenge in the Gram-negative world. Karen Bhttps://www.blogger.com/profile/15805000618118985786noreply@blogger.com